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Your healthcare provider will figure out the best treatment for you based on: A DNA test is needed to make a diagnosis of alpha thalassemia. In a pregnant woman, the baby is diagnosed using CVS ( chorionic villus sampling) or amniocentesis. This test is done to rule out iron-deficiency anemia.Īll of these tests can be done using a single blood sample. A lab test that tells what type of hemoglobin is present.įEP (free-erythrocyte protoporphyrin) and ferritin.
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Hemoglobin electrophoresis with A2 and F quantitation. This test checks the size, number, and maturity of different blood cells in a set volume of blood. The following tests may help to tell if you are a carrier, and can pass the disorder on to your children:Ĭomplete blood count (CBC). Babies with this type usually die before they are born.Īlpha thalassemia is most commonly found in these parts of the world: You have a greater risk of having a child with the most severe type, alpha thalassemia major.Īlpha thalassemia major. You may also have an enlarged liver or spleen, yellowish skin, and leg ulcers. These include lack of energy (fatigue) and exercise intolerance. This type causes moderate to severe symptoms. Or you may have mild symptoms such as mild fatigue or exercise intolerance. This type has no symptoms.Īlpha thalassemia carrier. Common symptoms for each type may include: What are the symptoms of alpha thalassemia?ĭifferent people will have different symptoms, based on which type of alpha thalassemia is inherited. The only risk factor is having a family history of the disease. This is a genetic disease inherited from one or both parents. In most cases, a baby with this condition will die before birth. You have a greater risk of having a child with alpha thalassemia major.Īlpha thalassemia major. They can also get worse if you are exposed to certain medicines, chemicals, or infectious agents. This is confirmed by DNA tests.Īlpha thalassemia carrier. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child. Your red blood cells may be smaller than normal. One gene is missing or damaged, and the other 3 are normal.
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What causes alpha thalassemia?Īlpha thalassemia occurs when some or all of the 4 genes that make hemoglobin (the alpha-globin genes) are missing or damaged.Īlpha thalassemia silent carrier. The severity and type of anemia depends on how many genes are affected. Anemia occurs when your body does not have enough red blood cells or hemoglobin. Thalassemia can cause mild or severe anemia. Different genes are affected for each type. There are 2 main types of thalassemia: alpha and beta. It carries oxygen to all parts of the body. Hemoglobin is an iron-rich protein in red blood cells. When you have thalassemia, your body makes less hemoglobin than normal. This means it is passed down from one or both parents through their genes. Get ready for Off Planet, the biggest and boldest adventure yet from the mind of Aileen Erin.Thalassemia (thal-uh-SEE-mee-uh) is a blood disorder that is inherited.
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